Long illness has mascerated his body so much so that he is reduced to flesh and bones.

Answer: Option B

Affected : influenced or touched by an external factor.
Soften : make or become soft or softer.
Devastated : destroy or ruin.
Wasted : used or expended carelessly or to no purpose.
Mascerated : to soften tissues after death by soaking and by enzymatic digestion.

Synonym of Mascerated is Soften