Major cause of Ozone depletion is due to which chemical?

Answer: Option A

Chlorofluorocarbons (CFCs) and other halogenated ozone depleting substances (ODS) are mainly responsible for man-made chemical ozone depletion. The total amount of effective halogens (chlorine and bromine) in the stratosphere can be calculated and are known as the equivalent effective stratospheric chlorine (EESC).