My uncle was so chagrined that he avoided mentioning the incident.

Answer: Option B

Pleased : feeling or showing pleasure and satisfaction, especially at an event or a situation.
Annoyed : slightly angry; irritated.
Happy : feeling or showing pleasure or contentment.
Tired : in need of sleep or rest; weary.
Chagrined : feel distressed or humiliated.

Synonym of Chagrined is Annoyed