One who despises his colleagues can never be successful.

Answer: Option C

Accuses : charge (someone) with an offence or crime.
Ignores : refuse to take notice of or acknowledge; disregard intentionally.
Hates : feel intense dislike for.
Discourages : cause (someone) to lose confidence or enthusiasm.
Despises : feel contempt or a deep repugnance for.

Synonym of Despises is Hates