Q237
Rate limiting enzyme in cholesterol biosynthesis
A.
α 1-4 glucosidase
B.
HMG-CoA reductase
AnswerC.
Squalene synthetase
D.
7 α-hydroxylase
Answer: Option B
Solution
Answer: Option B
Solution:
Rate limiting enzyme in cholesterol biosynthesis is HMG-CoA reductase.The biosynthetic pathway of cholesterol proceeds through several intermediates and involves different enzymes.
The rate-limiting step of cholesterol synthesis is the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase that synthesizes mevalonate starting from HMG-CoA.