Synonym of ESTRANGE

Answer: Option C

Puzzling : causing one to be puzzled; perplexing.
Endanger : put (someone or something) at risk or in danger.
Alienate : make (someone) feel isolated or estranged.
Miscaluculate : calculate (an amount or measurement) wrongly.
Estrange : cause (someone) to be no longer on friendly terms with someone.

Synonym of Estrange is Alienate