The great artist life was full of vicissitudes.

Answer: Option C

sorrows : a feeling of deep distress caused by loss, disappointment, or other misfortune suffered by oneself or others.
misfortunes : bad luck.
changes : make or become different.
surprises : an unexpected or astonishing event, fact, etc.
vicissitudes : a change of circumstances or fortune, typically one that is unwelcome or unpleasant.


Synonym of vicissitudes is changes