The incident frustrated all his ambitions.

Answer: Option D

Frustrated : feeling or expressing distress and annoyance resulting from an inability to change or achieve something.
Satiated : satisfy (a desire or an appetite) to the full.
Appeased : pacify or placate (someone) by acceding to their demands.
Cloyed : disgust or sicken (someone) with an excess of sweetness, richness, or sentiment.
Satisfied : contented; pleased.

Antonym of Frustrated is Satisfied