These recent developments seem to be quite adverse to our interests.

Answer: Option D

Favourable : expressing approval.
Indifferent : having no particular interest or sympathy; unconcerned.
Unfortunate : having or marked by bad fortune; unlucky.
Opposed : anxious to prevent or put an end to; disagreeing with.
Adverse : preventing success or development; harmful; unfavourable.

Synonym of Adverse is Opposed