Too many drugs are apt to cause distress.

Answer: Option B

Happiness : the state of being happy.
Depression : feelings of severe despondency and dejection.
Suffering : the state of undergoing pain, distress, or hardship.
Melancholy : a feeling of pensive sadness, typically with no obvious cause.
Distress : extreme anxiety, sorrow, or pain.

Synonym of Distress is Depression