Which one of the following changes occurs in a directionally migrating eukaryotic cell?
A. The ER is fragmented
B. The mitochondrial membrane potential drops
C. The nucleus moves towards the back and behind the Golgi
D. The Golgi is fragmented
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Structured William's model
P. Can describe the changes in intracellular components of the cell during growth.
Q. Cannot describe the death phase of the cells.
R. Can describe the variation of size of cells in the different phases of growth.
S. Cannot describe the lag period of growth.
Which one of the following is correct?
A. P, Q and S only
B. P, Q and R only
C. Q, R and S only
D. P, R and S only
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Metaplasia represents
A. Uncontrolled proliferation of cells initiated at the metaphase of cell cycle
B. Transformation of one differentiated cell type to another
C. Cell proliferation during metamorphosis
D. A measure of metabolic activity in hyperplastic cells
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Which one of the following organelles disappears during cell division and is regenerated in the daughter cells?
A. Endoplasmic reticulum
B. Golgi
C. Mitochondria
D. Peroxisomes
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The process by which intracellular macromolecules are supplied for lysosomal degradation during nutrient starvation is
A. Apoptosis
B. Autophagy
C. Phagocytosis
D. Pinocytosis
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The type of transport that does not reach Vmax , is
A. Simple diffusion across lipid bilayer
B. Facilitated diffusion via uniporters
C. Movement of ions through ion channels
D. Primary active transport via ATP powered pumps
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Neurotransmitter at the neuromuscular junction is
A. Epinephrine
B. Serotonin
C. Acetylcholine
D. Dopamine
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Which of the following statements about Na+ - K+ ATPase is correct?
A. It is responsible for generating the resting membrane potential
B. It transports Na+ and K+ ions down their respective gradients
C. It is responsible for generating an action potential
D. It indirectly regulates the volume of the cell
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Ras protein is a
A. Trimeric GTPase involved in relaying signal from cell surface to nucleus
B. Monomeric GTPase involved in relaying signal from cell surface to nucleus
C. Trimeric GTPase involved in regulation of cytoskeleton
D. Monomeric GTPase involved in regulation of cytoskeleton
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How many mitotic divisions shall occur to produce 64 cells from 2 cells
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Which one of the following intermediate filament proteins is present in the nucleus?
A. Vinculin
B. Lamin
C. Nestin
D. Laminin
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Secretory proteins synthesized by ER-associated ribosomes traverse through
A. Mitochondria
B. Peroxisomes
C. The Golgi apparatus
D. The nucleus
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Which one of the following result is expected when a mammalian cell in S-phase is fused with another in G2?
A. G2 phase nucleus will wait for S-phase nucleus to complete the replication and both the nuclei simultaneously enter into M-phase
B. S-phase nucleus would immediately enter into G2 phase without completing the replication phase
C. Both the nuclei would follow their corresponding cell cycle without influencing each other
D. Due to influence of S-phase promoting factor, G2-phase nucleus will enter into S-phase
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If a fluorescent dye is injected into the lumen of the endoplasmic reticulum (ER), in which of the following compartments can fluorescence signal can be observed?
A. ER only
B. Golgi only
C. ER and Golgi
D. ER, Golgi and nuclear envelope
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In a typical mitotic cell division cycle in eukaryotes, M phase occurs immediately after the
A. G0 phase
B. S phase
C. G1 phase
D. G2 phase
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In the course of cell cycle, the level of the protein cyclin abruptly falls during
A. G1 phase
B. S phase
C. G2 phase
D. M phase
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Hayflick limit of mammalian cells refers to which one of the following?
A. Cells in primary cell culture undergo senescence after 50-60 passages
B. Primary cells cultured in vitro do not cross the limit of cell transformation
C. Cell lines when cultured in vitro have a limit for their surface to volume ratio
D. Malignant cell lines undergo senescence after 50-60 passages
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A cargo has to be delivered from the centre of the cell to the cell periphery using the microtubule network. To which proteins does it need to be associated with
A. Dynein
B. Kinesin
C. Microtubule associated protein-4
D. Myosin
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Match the items in
Group I with
Group II .
Group I
Group II
P. Receptor tyrosine kinase
1. Inactivation of G-proteins
b. Q. Cyclic GMP (cGMP)
2. Reception of insulin signal
R. GTPase activating protein (GAP)
3. Thyroid hormone
S. Nuclear receptor
4. Receptor guanylyl cyclase
A. P-1, Q-3, R-4, S-2
B. P-2, Q-4, R-3, S-1
C. P-3, Q-1, R-4, S-2
D. P-2, Q-4, R-1, S-3
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In a migrating cell the relative position of the . . . . . . . . and the . . . . . . . . determines the polarity of the cell
A. Nucleus, Golgi
B. Golgi, Centriole
C. Nucleus, Mitochondria
D. Golgi, Mitochondria
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