The method used for prediction of three-dimensional structure of a protein from known structure(s) of one or more related proteins is
A. Multiple sequence alignment
B. Homology modeling
C. Phylogeny
D. Docking
Select an option to see the answer and solution.
Which one of the following BLAST search programs is used to identify homologs of a genomic DNA query in a protein sequence database?
A. Blastp
B. Blastn
C. Blastx
D. Tblastn
Select an option to see the answer and solution.
The multiple sequence alignment tool is . . .
A. Clastal W
B. SCOP
C. Gene bank
D. All of these
Select an option to see the answer and solution.
How many rooted and unrooted phylogenetic trees, respectively, are possible with four different sequences?
A. 3 and 15
B. 15 and 3
C. 15 and 12
D. 12 and 3
Select an option to see the answer and solution.
Identify the file format given below:
>P1; JMFD
Protein X - Homo sapiens
MKALT ARQQEVFDLIRDHISRTLRQQGDWL
Select an option to see the answer and solution.
The compound that has properties to become a drug is known as . . .
A. Fit drug
B. Fit compound
C. Lead
D. Find drug
Select an option to see the answer and solution.
Which one of the following tools is used to compare all the possible six-open reading frames of a given nucleotide query sequence with all the available six-open reading frames of the nucleotide sequence database?
A. BLASTN
B. BLASTX
C. TBLASTN
D. TBLASTX
Select an option to see the answer and solution.
In bioinformatics, the term 'BLAST' refers to
A. Database retrieval tool
B. Computational tool for sequence homology searching and alignment
C. Computational tool to view genomic sequences
D. Computational tool to view protein structures
Select an option to see the answer and solution.
Determine the correctness or otherwise of the following Assertion (A) and the Reason (R) .
Assertion: Ab initio gene finding algorithms that predict protein coding genes in eukaryotic genomes are not completely accurate.
Reason: Eukaryotic splice sites are difficult to predict.
A. Both (A) and (R) are false
B. (A) is true but (R) is false
C. Both (A) and (R) are true and (R) is the correct reason for (A)
D. Both (A) and (R) are true but (R) is not the correct reason for (A)
Select an option to see the answer and solution.
While searching a database for similar sequences, E-value does not depend on the
A. Sequence length
B. Number of sequences in the database
C. Scoring system
D. Probability from a normal distribution
Select an option to see the answer and solution.
The most widely used program for multiple sequence alignment is
A. BLAST
B. FASTA
C. CLUSTAL
D. Chime
Select an option to see the answer and solution.
The study of evolutionary relationships is known as
A. Genomics
B. Proteomics
C. Phylogenetics
D. Genetics
Select an option to see the answer and solution.
Program used for essentially local similarity search is
A. BLAST
B. RasMol
C. ExPASY
D. SWISS-PROT
Select an option to see the answer and solution.
The length of the minimum unique stretch of DNA sequence that can be found only once in a 3 billion base pairs long genome is
Select an option to see the answer and solution.
Which of the following statements are CORRECT when a protein sequence database is searched using the BLAST algorithm?
P. A larger E-value indicates higher sequence similarity.
Q. E-value < 10-10 indicates sequence homology.
R. A higher BLAST score indicates higher sequence similarity.
S. E-value > 10-10 indicates sequence homology.
A. P, Q and R only
B. Q and R only
C. P, R and S only
D. P and S only
Select an option to see the answer and solution.
Which one of the following is a database of protein sequence motifs?
A. PROSITE
B. TrEMBL
C. SWISSPROT
D. PDB
Select an option to see the answer and solution.
Which of the following is a model organism database?
A. GOLD SCOP
B. PRO
C. SGD GOL
D. SGD
Select an option to see the answer and solution.
Accession number is a unique identification assigned to a
A. Single database entry for DNA/Protein
B. Single database entry for DNA only
C. Single database entry for Protein only
D. Multiple database entry for DNA/Protein
Select an option to see the answer and solution.
An example of a derived protein structure database is
A. Pfam
B. SCOP
C. GEO
D. Prosite
Select an option to see the answer and solution.
The suitable substitution matrix to align closely related sequences is
A. PAM 250 or BLOSUM 80
B. PAM 40 or BLOSUM 80
C. PAM 120 or BLOSUM 40
D. PAM 250 or BLOSUM 40
Select an option to see the answer and solution.