A mutation in a gene that codes for a polypeptide results in a variant polypeptide that lacks the last three amino acids. What type of mutation is this?
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Molecular Biology and Genetics
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Match the entries in Group I with the entries in Group II.
| Group I | Group II |
| P. RNAse P | 1. Polyadenylation |
| Q. RNase H | 2. Splicing |
| R. snRNAs | 3. Ribozymes |
| S. CstF | 4. DNA-RNA hybrids |
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Topological winding number of a 2.0 kb covalently closed circular DNA was found to be 191 with a writhing number of -4. Hence, its linking number and the number of base pair per turn when the molecule is laid flat on the surface is . . . . . . . . and . . . . . . . ., respectively.
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PKU is one of the best-known hereditary disorders in amino acid metabolism. The defect is attributed to a lesion in one of the following enzymatic activities:
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A truncated polypeptide is synthesized due to a nonsense mutation. Where would you introduce another mutation to obtain a full-length polypeptide?
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Diploid Drosophila has eight chromosomes. Which one of the following terms should not be used to describe Drosophila with sixteen numbers of chromosomes?
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How many 3-tuples are possible for the following amino acid sequence?
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Molecular chaperones are class of proteins that facilitate
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Which one of the following is not a therapeutic agent based on nucleic acid for the treatment of genetic disorders?
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The enzyme that transcribes the eukaryotic genes encoding precursor ribosomal RNAs (pre-rRNAs) of 28S, 18S and 5.8S rRNAs is
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Caspases are involved in the process of
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Which of the following statements are true with respect to a special complex called 'dicer'?
P. It consists of deoxyribonuclease and DNA fragments.
Q. It consists of ribonuclease and RNA fragments.
R. It is involved in gene silencing.
S. It triggers apoptosis.
P. It consists of deoxyribonuclease and DNA fragments.
Q. It consists of ribonuclease and RNA fragments.
R. It is involved in gene silencing.
S. It triggers apoptosis.
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During transcription,
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What will be the binding status of regulatory proteins in lac operon when concentrations of both lactose and glucose are very low in the culture medium?
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The 5' ends of the mature forms of the prokaryotic mRNAs and tRNAs are
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Nuclease-hypersensitive sites in the chromosomes are sites that appear to be
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How many different protein sequences of 100 residues can be generated using 20 standard amino acids?
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The G + C content of bacteriophage M13 double stranded DNA is 68%. What would you expect the G + C content of its mRNA?
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Efficient expression of a heterologous protein product is influenced by
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The 4-amino or 4-keto group of pyrimidine bases is located in the
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