Which one of the following amino acids is catalyzed by activated macrophages to produce reactive nitrogen species?
A. Arginine
B. Asparagine
C. Cysteine
D. Histidine
Select an option to see the answer and solution.
Recombinant live attenuated vaccine against hepatitis B was prepared from
A. Plasma of chronically infected individual
B. Recombinant yeast expressing hepatitis B surface antigen
C. Recombinant vaccinia virus expressing hepatitis B surface antigen
D. Transgenic plants expressing hepatitis B surface antigen
Select an option to see the answer and solution.
Which of the following statements about immune response are correct?
P. T cells are activated by antigen-presenting cells.
Q. Foreign peptides are not presented to helper T cells by class II MHC proteins.
R. Dendritic cells are referred to as professional antigenpresenting cells.
A. P and R only
B. P and Q only
C. Q and R only
D. P, Q and R
Select an option to see the answer and solution.
Which one of the following complement proteins is the initiator of the membrane attack complex?
Select an option to see the answer and solution.
Which class of antibody is first made by developing B cells inside bone marrow?
Select an option to see the answer and solution.
Macrophages eliminate pathogenic bacteria upon activation by
A. NK cells
B. Basophils
C. CD4 + T cells
D. Plasma cells
Select an option to see the answer and solution.
Match the items
Group I with
Group II .
Group I
Group II
P. Programmed cell death at site of infection
1. TMV coat protein
Q. Hormone upregulated during flooding stress
2. EPSP synthase
R. Target for herbicide glyphosate
3. Hypersensitive response
S. Pathogen-derived resistance
4. Ethylene
A. P-1, Q-2, R-4, S-3
B. P-3, Q-4, R-2, S-1
C. P-1, Q-4, R-2, S-3
D. P-3, Q-2, R-4, S-1
Select an option to see the answer and solution.
Idiotypic determinants of an antibody are associated with the
A. Constant region of the heavy chains
B. Constant region of the light chains
C. Variable region
D. Constant regions of light and heavy chains
Select an option to see the answer and solution.
Interferon β is produced by
A. Bacteria infected cells
B. Virus infected cells
C. Both virus and bacteria infected cells
D. Fungi infected cells
Select an option to see the answer and solution.
Junctional diversity of antibody molecules results from
A. The addition of switch region nucleotides
B. The addition of N and P nucleotides
C. The joining of V, D and J segments
D. Mutations in complementarity-determining regions
Select an option to see the answer and solution.
Determine the correctness or otherwise of the following Assertion (A) and the Reason (R) .
Assertion: IgM is found in serum as a pentameric protein consisting of five IgM monomers.
Reason: The pentameric form of IgM is due to cross linking of IgM monomers via peptide bond.
A. Both (A) and (R) are true and (R) is the correct reason for (A)
B. Both (A) and (R) are true but (R) is not the correct reason for (A)
C. (A) is true but (R) is false
D. (A) is false but (R) is true
Select an option to see the answer and solution.
Which one of the following is NOT a part of the human non-specific defense system?
A. Interferon
B. Mucous
C. Saliva
D. Antibody
Select an option to see the answer and solution.
Match the immunoglobulin class in
Group I with its properties in
Group II .
Group I
Group II
P. IgG
1. Major antibody in external secretions such as bronchial mucus
Q. IgA
2. Protects against parasites
R. IgE
3. Antibody that appears first in serum after exposure to an antigen
S. IgM
4. Antibody present in highest concentration in serum
A. P-4, Q-1, R-2, S-3
B. P-3, Q-2, R-1, S-4
C. P-4, Q-3, R-1, S-2
D. P-1, Q-4, R-3, S-2
Select an option to see the answer and solution.
Reverse vaccinology indicates
A. From antigenic protein to vaccine development
B. From antigenic polysaccharide to vaccine development
C. From antibody to vaccine development
D. From genome sequence to vaccine development
Select an option to see the answer and solution.
Viral replication within cells is inhibited by
Select an option to see the answer and solution.
Antibody diversity is generated by
A. Protein splicing
B. Somatic mutation
C. Allelic exclusion
D. Inter-chromosomal recombination
Select an option to see the answer and solution.
Match items in
Group I with correct options from those given in
Group II .
Group I
Group II
P. Tissue plasminogen activator
1. Immunomodulator
Q. Gamma interferon
2. Biodegradable plastic
R. Podophyllotoxin
3. Clot dissolution
S. Polyhydroxyalkanoate
4. Anti-tumor agent
A. P-4, Q-3, R-1, S-2
B. P-1, Q-3, R-4, S-2
C. P-3, Q-1, R-2, S-4
D. P-3, Q-1, R-4, S-2
Select an option to see the answer and solution.
Gram-positive bacteria are generally resistant to complement-mediated lysis because
A. Thick peptidoglycan layer prevents insertion of membrane attack complex into the inner membrane
B. Gram-positive bacteria import the membrane attack complex and inactivate it
C. Membrane attack complex is degraded by the proteases produced by the Gram-positive bacteria
D. Gram-positive bacteria cannot activate the complement pathway
Select an option to see the answer and solution.
Reactions between antibodies and antigens that are detected by precipitate formation in an agar gel are referred as
A. Immunoprecipitation assay
B. Immunodiffusion assay
C. Immunoaggregation assay
D. Immunofixation assay
Select an option to see the answer and solution.
Based on the heavy chain, which one of the following antibodies has multiple subtypes?
Select an option to see the answer and solution.